Team Summary:
Just prior to the final Saturday practice session for the 2022 Italian Grand Prix the Williams team would announce that Alex Albon would be replaced for the remainder of the Italian GP by Nyck de Vries as the Williams driver was suffering from appendicitis. The session would start with a small number of drivers coming out including both Aston Martin's and AlphaTauri's. Perez would set a 1m:23.448 using the medium tyre followed by Bottas with just two cars running. Perez would improve with a 1m:22.611 as Tsunoda and Verstappen took to the track with ten minutes completed. Perez had improved with a 1m:22.148 as both Mercedes cars took to the circuit.

Verstappen would back off while running behind Russell going fourth only to have Russell move ahead. Both Ferrari's were now running along with Norris and Alonso. Verstappen was now quickest with a 1m:21.872 from Perez and Tsunoda. Leclerc was now third followed by Sainz, Alonso, Tsunoda, Norris, and Bottas eighth. Neither Williams had yet to come out with twenty minutes of the session completed. Both Williams cars were now running with the pair now 11th and 18th. Verstappen was still quickest from Leclerc, Perez, Sainz, Alonso, Gasly, Hamilton, Norris, Ocon and Tsunoda tenth. The track was now quite empty as both Williams cars continued to lap the Monza circuit. Both Williams drivers would pit and after a short wait we would see more drivers coming back out for soft tyre runs.

As laps were completed we would have Sainz second followed by Leclerc, Perez, Alonso, Norris, Russell and Nicholas eighth. Zhou would move into eighth seeing the Williams now ninth dropping to tenth. Verstappen would improve his quickest time with a 1m:21.252 as the quickest Williams was now 12th the next 13th. Leclerc was again second now followed by Perez, Sainz, Alonso, Norris, Russell, Tsunoda, Ocon and Hamilton tenth. The Williams drivers would finish the session in 13th and 14th which was an encouraging result given the situation that saw Nyck de Vries brought in at the last moment joined by the poor performances from Nicholas up to this session.

Nyck de Vries:
Nyck would finally get out with thirty five minutes remaining using the medium tyre. He would set a 1m:25.367 to be 18th briefly right behind his team-mate. But Nyck would have a moment taking to the gravel briefly. Nyck would improve with a 1m:24.790 remaining 18th. Nyck was just 0.5s behind Bottas who was on the soft tyre and Nyck the medium. A further improvement with a 1m:24.708 pitting after a ten lap run. He would quickly return remaining on used medium tyres. He would return having gained the experience of the pit entry and the stop. Nyck would return for a soft tyre run and would set a 1m:22.869 to be 13th right behind his team-mate. With the end of the session he would drop to 14th. He would get to complete a practice start from the grid with the end of the session.

Nicholas Latifi:
Nicholas would be the first car out in the session for Williams using the soft tyre. Nicholas would set a 1m:24.486 to be 17th. But with a 1m:23.552 Nicholas would improve to be tenth dropping to eleventh. He would pit after a eight lap run but would quickly return remaining on the used soft tyres. He would pit again and after a short delay he would return ion a new set of soft tyres. He would set a 1m:22.786 to be eighth dropping to tenth then twelfth. Nicholas would pit after a seven lap run. He would return to complete a practice start on the grid now 13th with the end of the session.