The second Friday practice for the 2016 United States Grand Prix would see the Williams drivers finish well down the times in fifteenth and sixteenth. Valtteri Bottas was again ahead of his team-mate Felipe Massa. The early part of the session had seen Felipe in the top ten in eighth while Valtteri Bottas was down the order in fifteenth. On there next run Valtteri would set a 1m:39.197 to move up to eighth and Felipe had dropped to tenth. With half of the session completed Valtteri would be in fourteenth and Felipe sixteenth. Felipe's time was a 1m:39.281. The session would be red flagged and with thirty minutes remaining both drivers would return to the track but would fail to improve their times for the session. In the later part of the session Felipe had told his engineer "The clutch is not working very well."

Pos  Driver         	Team		        Time     Laps
1  Nico Rosberg 	Mercedes 		1m37.358s 33 
2  Daniel Ricciardo 	Red Bull-Renault 	1m37.552s 33 
3  Lewis Hamilton 	Mercedes 		1m37.649s 32 
4  Sebastian Vettel 	Ferrari 		1m38.178s 35 
5  Max Verstappen 	Red Bull-Renault 	1m38.258s 27 
6  Nico Hulkenberg	Force India-Mercedes 	1m38.508s 32 
7  Sergio Perez 	Force India-Mercedes 	1m38.568s 31 
8  Jenson Button 	McLaren-Honda 		1m38.713s 29 
9  Fernando Alonso 	McLaren-Honda 		1m38.801s 30 
10 Kimi Raikkonen 	Ferrari 		1m38.865s 31 
11 Carlos Sainz 	Toro Rosso-Ferrari 	1m38.971s 31 
12 Kevin Magnussen 	Renault 		1m39.159s 23 
13 Felipe Nasr 		Sauber-Ferrari 		1m39.189s 28 
14 Valtteri Bottas 	Williams-Mercedes 	1m39.197s 34 
15 Daniil Kvyat 	Toro Rosso-Ferrari 	1m39.202s 36 
16 Felipe Massa 	Williams-Mercedes 	1m39.281s 30 
17 Jolyon Palmer 	Renault 		1m39.455s 34 
18 Romain Grosjean 	Haas-Ferrari 		1m39.554s 24 
19 Esteban Ocon 	Manor-Mercedes 		1m40.086s 27 
20 Esteban Gutierrez 	Haas-Ferrari 		1m40.114s 26 
21 Marcus Ericsson 	Sauber-Ferrari 		1m40.219s 28 
22 Pascal Wehrlein 	Manor-Mercedes 		1m41.131s 31