The second Friday practice for the 2010 Italian Grand Prix would get underway with a rush of drivers leaving the pit lane. Both Williams drivers, Nico Hulkenberg and Rubens Barrichello, were out early while Alguersuari would set the first time with a 1m:27.950. Petrov and De la Rosa would go faster with Petrov's time a 1m:25.290. Senna would stop just after leaving the pits ending his session. Nico would move up to second with a time of 1m:25.752. Rubens was in sixth with a 1m:26.622, but he would drop to seventh. Button was out on the track while Kubica went fastest with a 1m:24.822. Nico had moved ahead of Petrov with a 1m:24.891.

Button was now second with a 1m:24.829 followed by Nico, Petrov, Buemi, De la Rosa, Alguersuari, Sutil, Liuzzi, and Rubens now in tenth. Rubens was trying to make up for lost time after his input shaft failure in the opening practice session. The times continued to come down with Kubica setting a 1m:24.269 and Nico a 1m:24.366. Alonso was now in third, 1m:24.612, but Rubens would move ahead of the Ferrari with a 1m:24.410. Both Kubica and Nico would pit while Sutil would move up to fourth. Alonso was fifth from Button, Liuzzi, Petrov, Buemi, and De la Rosa. Button would go fastest with a time of 1m:24.062. Schumacher would copy Alguersuari's effort in the morning by taking to the gravel after running wide in the Parabolica. Alonso was now second with a 1m:24.264, while Button set a 1m:23.296 to be fastest by 0.968.

Alonso would improve with a 1m:23.925 but remained second. Both Williams drivers had pitted while the second Ferrari of Massa was able to move into seventh, 1m:24.726. Rosberg would jump up to fourth, 1m:24.325, seeing Nico fifth and Rubens sixth. Hamilton was still in his pit as his mechanics changed him to a low down force configuration. Massa would join Alonso at the front with a 1m:24.258 to be third. Rosberg would move ahead of Massa with a 1m:24.154. Webber was down in twelfth as Nico returned to the track while Button would pit. Neither Vettel of Hamilton had set a time with an hour and ten minutes remaining in the session. Button was fastest from Alonso, Rosberg, Massa, Kubica, Nico, Rubens, Sutil and Webber now in ninth. The top four weer all in their pits as Vettel set a 1m:24.674 to be tenth on his first timed lap.

Webber would pit while Rubens was also back out on the track. Hamilton's first lap time would see him eighteenth, 1m:25.638. Vettel was able to improve to be third, 1m:23.986, while Hamilton's next lap would see him move into second, 1m:23.869, to see a McLaren one-two. Nico and Rubens were now in eighth and ninth. Button would return to the track while both Williams drivers would pit. Kubica was now in fifth, 1m:24.133, with an hour left in the session. Nico would complain to his engineer about a very lose rear end. Hamilton would improve with a 1m:23.361 but remained second. Nico was now eighth while Rubens had dropped to tenth as Sutil had now split the Williams pair. Hamilton's next lap would see a very small improvement with a 1m:23.319. On his next lap he would go fastest
with a time of 1m:23.154.

Alonso was third but 0.771 behind Hamilton. With fifty five minutes remaining there was a lull in proceedings with fewer drivers on the track. Buemi would be the first driver to take on the option tyres but after a mistake at Roggia chicane he would pit. Both McLaren's had pitted while Rubens came back out. Vettel was back out followed by Webber. Webber would improve with a 1m:24.298 to be in eighth. Nico was now ninth and Rubens eleventh. Vettel was also on a quicker lap but a poor last sector would see him fail to move from fourth. Nico was back out on the track. Rubens would drop to twelfth as Petrov moved ahead of the Williams. Kubica was in a strong fifth with a time of 1m:24.133. It was reported that Senna's problem was fuel pressure related. Massa was up to fifth, 1m:24.100, while Alguersuari was out on the option tyre.

Massa was now third, 1m:23.891, while Button also took to the softer tyre. Vettel would pit while Rubens had also taken to his pit while Hamilton would return to the track also on the option tyre. Nico was also back in his pit while more drivers tried the option tyre. With thirty five minutes left Hamilton was still fastest from Button, Massa, Alonso, Vettel, Kubica, Rosberg, Webber, Nico, Sutil, Petrov, and Rubens in twelfth. Hamilton would pit after picking up some damage to the endplate of his front wing. Third placed Massa was back out while both McLaren's were back in the pits. Sutil would move up to eighth, 1m:24.276, seeing Nico drop to tenth. Vettel would leave his pit running the option tyres. It was now Rubens turn to return to the track as Massa set a 1m:23.289 to be third just behind Hamilton. His time was set on the option tyre while Vettel would move up to fourth with a 1m:23.311.

Massa's next lap was a 1m:23.283 as more drivers took to the track, including Nico. Kobayashi would take to the gravel at the second Lesmo corner but he was able to continue. Massa was now quickest with a 1m:23.061 with both McLaren's in their pits. Hamilton was now second from Button, Vettel, Alonso, Kubica, Rosberg, Sutil, Webber, and Nico in tenth. Both Williams drivers were out on the track with twenty five minutes left in the session. Massa was on a quicker lap while Button would return to the track. But Massa would run wide at the Parabolica seeing him take to the gravel and he would pit straight away. Team-mate Alonso would set a 1m:22.915 to go fastest but Vettel would
move ahead with a 1m:22.839. So Vettel was fastest from Alonso, Massa, Hamilton, Button, Webber, Rubens, Rosberg, Nico, and Kubica in tenth.

While Vettel and Massa had been swapping fastest times Rubens had move into seventh with a 1m:23.708. Nico's time was a 1m:24.009 as Rubens pitted. Nico would improve to be eighth with a 1m:23.852. For Webber his session would end as he lost drive in his Red Bull seeing him pull off the track at the Lesmo corners. With Rubens and Nico in seventh and eighth Nico would pit. Button was out on a long run while Hamilton had also come back out. Nico was back out on the track as Senna would stop again out on the track. Nico would pit while Rubens returned to the circuit. Nico would rive through the pit lane returning to the track. With seven minutes remaining while it was found that Webber had stopped after been told by his team that he had a water leak. Vettel was still fastest from Alonso, Massa, Hamilton, Button, Webber, Rubens, Kubica, Nico, and Rosberg in tenth.

As the final minutes counted down both Williams drivers were on longer runs on the option tyre. Both Williams drivers had completed thirty laps so far in the session. The session would come to an end with Nico already back in his pit. Vettel would make a mistake taking to the gravel at the Lesmo corner as he returned to his pit. Vettel would lead the second practice session at Monza for Red Bull Racing with a fastest time of 1m:22.839. For the AT&T Williams team it was a significantly improved session with Rubens and Nico in seventh and ninth. The Williams team was certainly the best of the rest with Red Bull, McLaren, and Ferrari dominating the top six positions.

Pos  Driver	    Team		    Time      Laps
 1.  Vettel         Red Bull-Renault        1:22.839  27
 2.  Alonso         Ferrari                 1:22.915  32
 3.  Massa          Ferrari                 1:23.061  20
 4.  Hamilton       McLaren-Mercedes        1:23.154  22
 5.  Button         McLaren-Mercedes        1:23.210  38
 6.  Webber         Red Bull-Renault        1:23.415  23
 7.  Barrichello    AT&T Williams-Cosworth  1:23.708  31
 8.  Kubica         Renault                 1:23.709  32
 9.  Hulkenberg     AT&T Williams-Cosworth  1:23.852  30
10.  Rosberg        Mercedes                1:23.857  29
11.  Sutil          Force India-Mercedes    1:24.181  35
12.  Liuzzi         Force India-Mercedes    1:24.380  36
13.  Petrov         Renault                 1:24.407  21
14.  Schumacher     Mercedes                1:24.448  29
15.  Buemi          Toro Rosso-Ferrari      1:24.517  35
16.  de la Rosa     Sauber-Ferrari          1:24.547  32
17.  Kobayashi      Sauber-Ferrari          1:24.785  31
18.  Alguersuari    Toro Rosso-Ferrari      1:25.106  24
19.  Trulli         Lotus-Cosworth          1:26.204  38
20.  Kovalainen     Lotus-Cosworth          1:26.306  41
21.  di Grassi      Virgin-Cosworth         1:26.631  31
22.  Glock          Virgin-Cosworth         1:26.676  25
23.  Yamamoto       HRT-Cosworth            1:29.498  5
24.  Senna          HRT-Cosworth                      3